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| Product Name | NMDAR2C/2D Inhibitor, DQP-1105 (DQP-1105, NMDA Antagonist IV) |
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| Description | Purity ~97% (HPLC). A dihydroquinilone-pyrazoline NMDA antagonist, which is selective for NMDA receptors that are comprised of recombinant subunits GluN1/GluN2C (IC50 = 5.4uM) and GluN1/GluN2D (2.2uM) over GluN1/GluN2B (206uM) and GluN1/ClucN2A (undetectable) in Xenopus oocytes. Similar selectivity is observed in whole-cell HEK patch-clamp assays with IC50 values for GluN2C and GluN2D that are at least 50-fold lower than those for recombinant GluN2A, GluN2B, GluA1, or GluK2-containing receptors. It inhibits NMDA by blocking a conformational change necessary for channel opening and is non-competitive with co-agonists, glutamate and glycine. Formula: C29H24BrN3O4 Solubility: DMSO Molecular Weight: 558.4 |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217594 |
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| Order / More Info | NMDAR2C/2D Inhibitor, DQP-1105 (DQP-1105, NMDA Antagonist IV) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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