| 产品详情 |
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| Product Name | PF-429242 (hydrochloride) |
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| Description | A site-1 protease inhibitor (IC50 =170 nM against human recombinant site-1 protease); selective for site-1 protease over trypsin, elastase, proteinase K, plasmin, kallikren, factor XIa, thrombin, and furin at concentrations up to 100 µM; inhibits proteolytic processing and nuclear translocation of SREBP; reduces expression of HMG-CoA synthase and fatty acid synthase (EC50s = 0.3 and 2 µM, respectively) and inhibits cholesterol synthesis (EC50 = 600 nM) in HepG2 cells; reduces cholesterol and fatty acid synthesis in CD-1 mice; inhibits replication of dengue virus serotypes 1-4 in infected HeLa cells; reduces growth of T98G, U87-MG, and A172 glioblastoma cells (IC50s = 0.32, 15.2, and 27.6 µM, respectively), |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | PF429242 947303-87-9 Hep-G2 HMGCoA CD1 U87MG A-172 S1P coenzyme A Hydroxymethylglutaryl FAS |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 15140-10 |
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| Price | |
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| Order / More Info | PF-429242 (hydrochloride) from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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