| 产品详情 |
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| Product Name | (±)5(6)-EET |
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| Description | Purity >95%. 5(6)-EET is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes. In solution, 5(6)-EET degrades into 5,6-DiHET and 5(6)-Delta-lactone, which can be converted to 5(6)-DiHET and quantified by GC-MS. In neuroendocrine cells, such as the anterior pituitary and pancreatic islets, 5(6)-EET has been implicated in the mobilization of calcium and hormone secretion. 5(6)-EET is an inhibitor of T-type voltage-gated calcium channels (Cav 3) that inhibits isoforms Cav 3.1, Cav 3.2 (IC50 = 0.54 µM), and Cav 3.3 and decreases nifedipine-resistant phenylephrine-induced vasoconstriction in isolated mouse mesenteric arteries via Cav 3.2 blockade when used at a concentration of 3 µM. In addition, it is a substrate of COX-1 and COX-2, as measured by oxygen consumption and product formation assays when used at a concentration of 50 µM. (±)5(6)-EET is provided as a mixture of the free acid and lactone. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (±)5,6-epoxy-8Z,11Z,14Z-eicosatrienoic acid, (±)5,6-EpETrE |
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| Gene, Accession, CAS # | CAS: 87173-80-6 |
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| Catalog # | LS-H5529 |
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| Price | |
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| Order / More Info | (±)5(6)-EET from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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