产品名称 Activated c1s Antibody from ANTIBODIES-ONLINE GmbH
产品货号 ABIN2191987
产品价格 现货询价,电话:010-67529703
产品规格 100 µg
产品品牌 ANTIBODIES-ONLINE GmbH
产品概述
产品详情
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Antigenic SpecificityActivated c1s
CloneM241
Host SpeciesMouse
Reactive Specieshuman
Isotypen/a
Formatunconjugated
Size100 µg
Concentrationn/a
ApplicationsImmunoassay (IA),Western Blotting (WB),Immunoprecipitation (IP),Flow Cytometry (FACS),Immunohistochemistry (Frozen Sections) (IHC (fro)),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)),Inhibition Assay (InhA)
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DescriptionMonoclonal antibody M241 reacts with an epitope on human C protein activated C1s, a subcomponent of the first component of C (C1). Activated C1s is a glycosylated single-polypeptide zymogen of 85 kD. Activation of the proenzyme C1s occurs through cleavage by the active form of C1r. The activated protease, activated C1s, consists of a disulfide-linked H chain and a L chain. Activated C1s is a serine protease and its catalytic site is located in the L chain. Activation of the classical C pathway is triggered by activated C1s which cleaves C4 and C2 to form the C3 convertase, C4bC2a. The epitope recognised by the antibody M241 is domain IV and/or V of the gamma-domain of activated C1s. Monoclonal antibody M241 blocks C4 activation and C4 binding to activated C1s. The antibody binds specifically to the active centre of C1s.
Immunogenn/a
Other Namesn/a
Gene, Accession #n/a
Catalog #ABIN2191987
Price
Order / More InfoActivated c1s Antibody from ANTIBODIES-ONLINE GmbH
Product Specific ReferencesPubMed: 2522968
产品资料