| 产品详情 |
| Edit |   |
|---|
| Product Name | Recombinant Human NADPH oxidase 4 (NOX4), partial |
|---|
| Description | Purity > 85% as determined by SDS-PAGE. MW: 28.8kDa. Partial: 210-424aa. N-terminal 6xHis-tagged. Homo sapiens (Human). Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 5 and isoform 6 display reduced activity. Isoform 4: Involved in redox signaling in vascular cells. Constitutively and NADPH-dependently generates reactive oxygen species (ROS). Modulates the nuclear activation of ERK1/2 and the ELK1 transcription factor, and is capable of inducing nuclear DNA damage. Displays an increased activity relative to isoform 1. |
|---|
| Size | 100ug |
|---|
| Concentration | n/a |
|---|
| Applications | RUO |
|---|
| Other Names | Kidney oxidase-1; KOX-1; Kidney superoxide-producing NADPH oxidase; Renal NAD (P)H-oxidase; RENOX |
|---|
| Gene, Accession, CAS # | NOX4, UniProt: Q9NPH5 |
|---|
| Catalog # | RPC25645 |
|---|
| Price | |
|---|
| Order / More Info | Recombinant Human NADPH oxidase 4 (NOX4), partial from BIOMATIK |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|