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| Product Name | Porcn Inhibitor III, IWP-L6 (IWPL6, Wnt Pathway Inhibitor XIX) |
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| Description | Purity ~99% (HPLC). A cell-permeable pyridinyl-phenylacetamide that is reported to be 60-times more potent than IWP-2 in suppressing autonomous Wnt signaling in murine L-Wnt-STF fibroblasts (IC50 = 0.5nM) and 100-times more potent in blocking branching morphogenesis in cultured murine embryonic kidney (complete blockage at 50nM). Also shown to be at least twice as potent as TNKS inhibitor IWR-1 in preventing the regeneration of severed zebrafish tailfin and in inhibiting zebrafish embryo prosterior axis formation (Effective conc = 5uM). Its susceptibility to metabolization by serum carboxylesterase limits its in vivo use in rats and mice. Solubility: DMSO Primary Target: Porcupine |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217684 |
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| Order / More Info | Porcn Inhibitor III, IWP-L6 (IWPL6, Wnt Pathway Inhibitor XIX) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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