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| Product Name | Porcn Inhibitor II, C59 |
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| Description | Purity ~99% (HPLC). A cell-permeable pyridinylphenyl-acetamide that is much more potent than IWP-2 in inhibiting MBOAT family member Porcupine-mediated Wnt palmitoylation (IC50 = 74 pM in STF reporter assays using Wnt3a-transfected HEK293). Shown to be effective against Porcn of murine and human, but not xenopus, species and potently inhibit the processing of both canonical and non-canonical Wnt subtypes. C59 is demonstrated to be orally active and effectively suppress MMTV-WNT1 tumor expansion in mice (5mg/kg & 10mg/kg p.o.) in vivo. Solubility: DMSO Primary Target: Porcupine (Porcn)-mediated Wnt palmitoylation |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Porcn Inhibitor II, C59 (Wnt-C59, Wnt Pathway Inhibitor XVI, 2-(4-(2-Methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetamide) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217683 |
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| Order / More Info | Porcn Inhibitor II, C59 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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