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| Product Name | Prodigiosin, Serratia marcescens |
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| Description | Purity ~95% (HPLC). A cell-permeable tripyrrole alkaloid compound that displays immunosuppressive and anti-tumor properties irrespective of p53 status and multidrug resistance. Shown to selectively upregulate p21WAF/CIP1 and NAG-1 (nonsteroidal anti-inflammatory drug-activated gene 1) and downregulate survivin expression levels, induce mitochondria-mediated apoptosis and cell cycle arrest in tumor cells. Prevents FADD phosphorylation (IC50=2.0uM in A549-FKR cells) through inhibition of FADD-kinase CK1a (IC50 ~6.0uM in SW620-BGCR cells) and augments cisplatin -induced apoptosis. Blocks NF-kB activation by decreasing plkBa (by 63% at 3uM) and lkBa levels in A549 cells, and shrinks tumor growth in A549-FKR tumor xenograft mouse model (3mg/kg, i.p., o.d.). Formula: C20H25N3O Molecular Weight: 323.4 Solubility: DMSO, DMF, EtOH, MeOH |
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| Size | 200ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Prodigiosin, Serratia marcescens (NSC 47147, Casein Kinase I Inhibitor IV, 2-Methyl-3-pentyl-6-methoxyprodigiosene) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217703 |
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| Order / More Info | Prodigiosin, Serratia marcescens from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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