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| Antigenic Specificity | DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (pTyr399) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | affinity purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Methylation of DNA at cytosine residues in mammalian cells is a heritable, epigenetic modification that is critical for proper regulation of gene expression, genomic imprinting and development. Three families of mammalian DNA methyltransferases have been identified: DNMT1, DNMT2 and DNMT3. DNMT1 is constitutively expressed in proliferating cells and functions as a maintenance methyltransferase, transferring proper methylation patterns to newly synthesized DNA during replication. DNMT3A and DNMT3B are strongly expressed in embryonic stem cells with reduced expression in adult somatic tissues. DNMT3A and DNMT3B function as de novo methyltransferases that methylate previously unmethylated regions of DNA. DNMT2 is expressed at low levels in adult somatic tissues and its inactivation affects neither de novo nor maintenance DNA methylation. DNMT1, DNMT3A and DNMT3B together form a protein complex that interacts with histone deacetylases (HDAC1, HDAC2, Sin3A), transcriptional repressor proteins (RB, TAZ-1) and heterochromatin proteins (HP1, SUV39H1), to maintain proper levels of DNA methylation and facilitate gene silencing. Improper DNA methylation contributes to diseased states such as cancer. Hypermethylation of promoter CpG islands within tumor suppressor genes correlates with gene silencing and the development of cancer. In addition, hypomethylation of bulk genomic DNA correlates with and may contribute to the onset of cancer. DNMT1, DNMT3A and DNMT3B are over-expressed in many cancers, including acute and chronic myelogenous leukemias, in addition to colon, breast and stomach carcinomas.Synonyms: DNMT1, AIM, DNMT, MCMT, CXXC9, HSN1E, FLJ16293, MGC104992 |
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| Immunogen | A phospho specific peptide corresponding to residues surrounding pTyr399 of human Dnmt1 |
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| Other Names | cb1075|cb983|dmnt1|fb05h01|mta|wu:fb05h01|ADCADN|AIM|CXXC9|DNMT|HSN1E|MCMT|DDM2|DECREASED DNA METHYLATION 2|DMT01|DMT1|DNA METHYLTRANSFERASE|DNA METHYLTRANSFERASE 01|DNA METHYLTRANSFERASE 1|MET2|METHYLTRANSFERASE 2|METHYLTRANSFERASE I|METI|methyltransferase 1|Cxxc9|Dnmt|Dnmt1o|MTase|Met-1|Met1|MommeD2|m.MmuI |
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| Gene, Accession # | Gene ID: 1786 |
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| Catalog # | ABIN1513341 |
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| Order / More Info | DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (pTyr399) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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