产品名称 DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (pTyr399) Antibody from ANTIBODIES-ONLINE GmbH
产品货号 ABIN1513341
产品价格 现货询价,电话:010-67529703
产品规格 100 µg
产品品牌 ANTIBODIES-ONLINE GmbH
产品概述
产品详情
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Antigenic SpecificityDNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (pTyr399)
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman
Isotypen/a
Formataffinity purified
Size100 µg
Concentrationn/a
ApplicationsWestern Blotting (WB)
Reviews / RatingsIf you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
DescriptionMethylation of DNA at cytosine residues in mammalian cells is a heritable, epigenetic modification that is critical for proper regulation of gene expression, genomic imprinting and development. Three families of mammalian DNA methyltransferases have been identified: DNMT1, DNMT2 and DNMT3. DNMT1 is constitutively expressed in proliferating cells and functions as a maintenance methyltransferase, transferring proper methylation patterns to newly synthesized DNA during replication. DNMT3A and DNMT3B are strongly expressed in embryonic stem cells with reduced expression in adult somatic tissues. DNMT3A and DNMT3B function as de novo methyltransferases that methylate previously unmethylated regions of DNA. DNMT2 is expressed at low levels in adult somatic tissues and its inactivation affects neither de novo nor maintenance DNA methylation. DNMT1, DNMT3A and DNMT3B together form a protein complex that interacts with histone deacetylases (HDAC1, HDAC2, Sin3A), transcriptional repressor proteins (RB, TAZ-1) and heterochromatin proteins (HP1, SUV39H1), to maintain proper levels of DNA methylation and facilitate gene silencing. Improper DNA methylation contributes to diseased states such as cancer. Hypermethylation of promoter CpG islands within tumor suppressor genes correlates with gene silencing and the development of cancer. In addition, hypomethylation of bulk genomic DNA correlates with and may contribute to the onset of cancer. DNMT1, DNMT3A and DNMT3B are over-expressed in many cancers, including acute and chronic myelogenous leukemias, in addition to colon, breast and stomach carcinomas.Synonyms: DNMT1, AIM, DNMT, MCMT, CXXC9, HSN1E, FLJ16293, MGC104992
ImmunogenA phospho specific peptide corresponding to residues surrounding pTyr399 of human Dnmt1
Other Namescb1075|cb983|dmnt1|fb05h01|mta|wu:fb05h01|ADCADN|AIM|CXXC9|DNMT|HSN1E|MCMT|DDM2|DECREASED DNA METHYLATION 2|DMT01|DMT1|DNA METHYLTRANSFERASE|DNA METHYLTRANSFERASE 01|DNA METHYLTRANSFERASE 1|MET2|METHYLTRANSFERASE 2|METHYLTRANSFERASE I|METI|methyltransferase 1|Cxxc9|Dnmt|Dnmt1o|MTase|Met-1|Met1|MommeD2|m.MmuI
Gene, Accession #Gene ID: 1786
Catalog #ABIN1513341
Price
Order / More InfoDNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (pTyr399) Antibody from ANTIBODIES-ONLINE GmbH
Product Specific Referencesn/a
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