产品名称 DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (aa 637-650) Antibody from ANTIBODIES-ONLINE GmbH
产品货号 ABIN2486006
产品价格 现货询价,电话:010-67529703
产品规格 100 µg
产品品牌 ANTIBODIES-ONLINE GmbH
产品概述
产品详情
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Antigenic SpecificityDNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (aa 637-650)
Clone60B1220-1
Host SpeciesMouse
Reactive Specieshuman, mouse, zebrafish
Isotypen/a
Formatfluorescein (FITC) conjugate
Size100 µg
Concentrationn/a
ApplicationsChromatin Immunoprecipitation (ChIP),Immunohistochemistry (IHC),Immunoprecipitation (IP),Western Blotting (WB)
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DescriptionMethylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. To date, 3 families of mammalian DNA methyltransferase genes have been identified which include Dnmt1, Dnmt2 and Dnmt3. Dnmt1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality. Dnmt2 is expressed at low levels in adult tissues and its inactivation does not affect DNA methylation or maintenance of methylation. The Dnmt3 family members, Dnmt3a and Dnmt3b, are strongly expressed in ES cells but their expression is down regulated in differentiating ES cells and is low in adult somatic tissue. Dnmt1 co-purifies with the retinoblastoma (Rb) tumour suppressor gene product, E2F1, and HDAC1. Dnmt1 also cooperates with Rb to repress transcription from promoters containing E2F-binding sites suggesting a link between DNA methylation, histone deacetylase and sequence-specific DNA binding activity, as well as a growth-regulatory pathway that is disrupted in nearly all cancer cells.Cellular Localization: Nucleus
ImmunogenRaised against a synthetic peptide corresponding to amino acids 637-650 of human DNMT1
Other Namescb1075|cb983|dmnt1|fb05h01|mta|wu:fb05h01|ADCADN|AIM|CXXC9|DNMT|HSN1E|MCMT|DDM2|DECREASED DNA METHYLATION 2|DMT01|DMT1|DNA METHYLTRANSFERASE|DNA METHYLTRANSFERASE 01|DNA METHYLTRANSFERASE 1|MET2|METHYLTRANSFERASE 2|METHYLTRANSFERASE I|METI|methyltransferase 1|Cxxc9|Dnmt|Dnmt1o|MTase|Met-1|Met1|MommeD2|m.MmuI
Gene, Accession #Gene ID: 30430,1786,13433
Catalog #ABIN2486006
Price
Order / More InfoDNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (aa 637-650) Antibody from ANTIBODIES-ONLINE GmbH
Product Specific ReferencesPubMed: 10433969, 10555141, 10581015
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