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| Product Name | Recombinant Human Dr1-associated corepressor protein |
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| Description | 4-198aa; Partial. MW: 48.6kD. Purity >90% as determined by SDS-PAGE. The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. |
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| Size | 0.01 mg, 0.05 mg, 0.1 mg, 0.2 mg, 0.5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [Dr1-associated protein 1; Negative cofactor 2-alpha; NC2-alpha] |
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| Gene, Accession, CAS # | DRAP1, Gene ID: 10589, Accession: NP_006433.2 |
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| Catalog # | MBS717353 |
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| Order / More Info | Recombinant Human Dr1-associated corepressor protein from MYBIOSOURCE INC. |
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| Product Specific References | A mechanism for repression of class II gene transcription through specific binding of NC2 to TBP-promoter complexes via heterodimeric histone fold domains.Goppelt A.R., Stelzer G., Lottspeich F., Meisterernst M.EMBO J. 15:3105-3116(1996) Requirement of a corepressor for Dr1-mediated repression of transcription.Mermelstein F., Yeung K., Cao J., Inostroza J.A., Erdjument-Bromage H., Eagelson K., Landsman D., Levitt P., Tempst P., Reinberg D.Genes Dev. 10:1033-1048(1996) NC2alpha interacts with BTA |
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