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| Antigenic Specificity | ISG15 Ubiquitin-Like Modifier (ISG15) (aa 1-157) |
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| Clone | P3E5AT |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | unconjugated |
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| Size | 20 µg |
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| Concentration | n/a |
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| Applications | ELISA,Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | ISG15 ubiquitin-like Modifier is conjugated to the intracellular target proteins after IFN-alpha or IFN-beta stimulation. ISG15 enzymatic pathway is partially distinct from that of ubiquitin, differing in substrate specificity and interaction with ligating enzymes. ISG15 conjugation pathway uses a dedicated E1 enzyme, but seems to converge with the ub conjugation pathway at the level of a specific E2 enzyme. ISG15 protein targets include STAT1, SERPINA 3G/SPI2A, JAK1, MAPK3/ERK1, PLCG1, EIF2AK2/PKR, MX1/MXA, and RIG-1. Deconjugated by USP18/UBP43 shows specific chemotactic activity towards neutrophils and activates them to induce release of eosinophil chemotactic factors. ISG15 serves as a trans-acting binding factor directing the association of ligated target proteins to intermediate filaments. ISG15 plays a role in autocrine, paracrine and endocrine mechanisms, as in cell-to-cell signaling, possibly partly by inducing ifn-gamma secretion by monocytes and macrophages. ISG15 displays a.Synonyms: ISG15, G1P2, IFI15, UCRP, Interferon-induced 17 kDa protein precursor, ISG15 Ubiquitin-like modifier |
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| Immunogen | Anti-human ISG15 mAb is derived from hybridization of mouse SP2/0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human ISG15 AA 1-157 |
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| Other Names | g1p2|zfISG15|si:rp71-1c23.2|ISG15|G1P2|IFI15|IP17|UCRP|hUCRP|G1p2|IGI15|Irfp |
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| Gene, Accession # | Gene ID: 9636 |
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| Catalog # | ABIN808581 |
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| Order / More Info | ISG15 Ubiquitin-Like Modifier (ISG15) (aa 1-157) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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