| 产品详情 |
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| Antigenic Specificity | ISG15 Ubiquitin-Like Modifier (ISG15) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | mouse, rat, human |
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| Isotype | n/a |
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| Format | affinity purified |
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| Size | 50 µg |
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| Concentration | n/a |
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| Applications | Western Blotting (WB),Immunohistochemistry (IHC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Interferon-stimulated 15 kDa protein (ISG15), also known as ubiquitin cross-reactive protein (UCRP), is a member of the ubiquitin-like protein family and functions in various biological pathways from pregnancy to innate immune responses . Expression of ISG15 is stimulated by cellular exposure to type 1 interferons alpha and beta, in addition to infection with viruses such as influenza B . After exposure to type I interferons, both lymphocytes and monocytes, in addition to some fibroblasts and epithelial cells, release ISG15 into culture medium . ISG15 has been shown to function as a cytokine, stimulating interferon gamma secretion by monocytes and macrophages, proliferation of natural killer cells, and chemotactic responses in neutrophils . ISG15 has also been shown to function intracellularly, being covalently conjugated to other proteins by E1 (Ube1L), E2 (UbcH8) and E3 ligases via a multi-step process analogous to ubiquitination . ISG15 is removed from proteins by the ubiquitin processing protease Ubp43 . ISG15-protein conjugation (ISGylation) is induced by type 1 interferons, and target proteins include the serine protease inhibitor Serpin 2A, PLCgamma1, ERK1/2, Jak1 and Stat1 . Unlike ubiquitination, ISGylation does not target proteins for degradation, rather ISGylation increases Jak1 and Stat1 activity, enhancing the cellular response to interferons . Synonyms: ISG15,G1P2,IFI15,UCRP , |
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| Immunogen | Recombinant protein of human ISG15 |
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| Other Names | g1p2|zfISG15|si:rp71-1c23.2|ISG15|G1P2|IFI15|IP17|UCRP|hUCRP|G1p2|IGI15|Irfp |
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| Gene, Accession # | Gene ID: 9636,100038882,298693 |
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| Catalog # | ABIN1683708 |
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| Price | |
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| Order / More Info | ISG15 Ubiquitin-Like Modifier (ISG15) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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