| 产品详情 |
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| Product Name | APS-2-79 (hydrochloride) |
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| Description | An inhibitor of KSR-dependent MAPK signaling; inhibits ATPbiotin binding to KSR2 in KSR2-MEK1 complexes (IC50 = 120 nM); stabilizes KSR2 in an inactive state; reduces interactions between B-RAF and KSR2-MEK1 complexes; inhibits KSR-stimulated phosphorylation of MEK and ERK in HEK293H cells at 5 µM; enhances the efficacy of trametinib, further reducing cell viability in K-Ras mutant HCT116 and A549 cell lines, but not B-RAF mutant SK-MEL-239 and A375 cell lines, at 1 µM |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2002381-25-9 APS2-79 APS279 APS-279 BRAF MAPKK KSR-2 MEK-1 HEK-293H 293-H SKMEL239 SKMEL MEL239 A-375 HCT- 116 A-549 |
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| Gene, Accession, CAS # | CAS: 2002381-31-7 |
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| Catalog # | 22137-10 |
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| Price | |
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| Order / More Info | APS-2-79 (hydrochloride) from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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