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| Antigenic Specificity | Natural Cytotoxicity Triggering Receptor 1 (NCR1) (aa 22-255) |
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| Clone | Pn1D9AT |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | unconjugated |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Immunofluorescence (Cultured Cells) (IF (cc)),Flow Cytometry (FACS) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | A natural cytotoxicity receptor (NCR) NKp46 has been shown to represent a novel NK cell-specific molecule involved in human NK cell activation. The natural cytotoxicity receptors (NCRs) are a recently characterized family of Ig-like activation receptors that appear to be major triggering receptors in tumor cell recognition. The three known NCRs include NKp46 and NKp30, which are expressed on circulating NKcells, and NKp44, which is expressed only on activating NK cells. NKp46 has been implicated in NK cell-mediated lysis of several autologous tumor cells, pathogen-infected cell lines and mononuclear phagocytes infected with an intracellular bacterium. The Lysis of tumor cells by NK-cells involves recognition by NKp46 of heparan sulfate moieties of membrane heparan sulfate proteoglycans. Furthermore, NKp46 is a surface receptor involved in NK-cell cell death by apoptosis. NKp46 has two extracellular Ig-like domains followed by a 40 residue stalk region, a type I transmembrane domain, a.Synonyms: Natural cytotoxicity triggering receptor 1, Natural killer cell p46-related protein, hNKp46, NK-p46, NKp46, NK cell-activating receptor, Lymphocyte antigen 94 homolog, CD335 antigen, NCR1, LY94, NCRNKp46, CD335 |
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| Immunogen | Anti-human NKp46 mAb, is derived from hybridization of mouse SP2/0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human NKp46 AA 22-255 |
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| Other Names | CD335|LY94|NK-p46|NKP46|Ly94|NKp46|KILR-1|Nk-p46|Nkp46 |
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| Gene, Accession # | Gene ID: 9437 |
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| Catalog # | ABIN808493 |
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| Order / More Info | Natural Cytotoxicity Triggering Receptor 1 (NCR1) (aa 22-255) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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