产品名称 NMDA Receptor 1 (NMDAR1) (NR2B Subunit), (pTyr1252) Antibody from ANTIBODIES-ONLINE GmbH
产品货号 ABIN361483
产品价格 现货询价,电话:010-67529703
产品规格 100 µL
产品品牌 ANTIBODIES-ONLINE GmbH
产品概述
产品详情
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Antigenic SpecificityNMDA Receptor 1 (NMDAR1) (NR2B Subunit), (pTyr1252)
Clonepolyclonal
Host SpeciesRabbit
Reactive Speciesrat
Isotypen/a
Formataffinity purified
Size100 µL
Concentrationn/a
ApplicationsWestern Blotting (WB),Immunohistochemistry (IHC)
Reviews / RatingsIf you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
DescriptionThe NMDA receptor (NMDAR) plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's, epilepsy and ischemic neuronal cell death (Grosshans et al., 2002, Wenthold et al., 2003, Carroll and Zukin, 2002). The rat NMDAR1 (NR1) was the first subunit of the NMDAR to be cloned. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits (Ishii et al., 1993). Phosphorylation of Tyr1252 is thought to potentiate NMDA receptor-dependent influx of calcium (Takasu et al., 2002). Anti-Phospho-Tyr1252 NMDA Receptor NR2B Subunit Western blot of rat hippocampal lysate showing specific immunolabeling of the ~180k NR2B subunit of the NMDAR phosphorylated at Tyr1252 (Control). The phosphospecificity of this labeling is shown in the second lane (lambda-phosphatase: (-Ptase). The blot is identical to the control except that it was incubated in (-Ptase (1200 units for 30 min) before being exposed to the phospho-Tyr1252 NMDA NR2B subunit antibody. The immunolabeling is completely eliminated by treatment with (-Ptase.
Immunogenn/a
Other NamesCG2902|DMNMDAR1|DNMDAR-I|DNmdar|DmelNmdar1|Dmel\\CG2902|DrNR1|NMDA|NMDA R1|NMDAR1|NMdar1|NR1|NRI|Nmdar|dNR1|dnmdar-I|nmr
Gene, Accession #n/a
Catalog #ABIN361483
Price
Order / More InfoNMDA Receptor 1 (NMDAR1) (NR2B Subunit), (pTyr1252) Antibody from ANTIBODIES-ONLINE GmbH
Product Specific ReferencesPubMed: 21896318, 11799243, 12392932, 11740502, 8428958, 12540744
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