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| Antigenic Specificity | EF-Hand Calcium Binding Domain 4B (EFCAB4B) (Middle Region) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | affinity purified |
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| Size | 50 µg |
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| Concentration | n/a |
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| Applications | Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | EFCAB4B is a Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. It acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex. |
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| Immunogen | EFCAB4 B antibody was raised using the middle region of EFCAB4 corresponding to a region with amino acids KNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQ |
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| Other Names | CRACR2A|Gm1073|Gm462 |
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| Gene, Accession # | Gene ID: 84766 |
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| Catalog # | ABIN631725 |
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| Price | |
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| Order / More Info | EF-Hand Calcium Binding Domain 4B (EFCAB4B) (Middle Region) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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