产品名称 EF-Hand Calcium Binding Domain 4B (EFCAB4B) (Middle Region) Antibody from ANTIBODIES-ONLINE GmbH
产品货号 ABIN631725
产品价格 现货询价,电话:010-67529703
产品规格 50 µg
产品品牌 ANTIBODIES-ONLINE GmbH
产品概述
产品详情
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Antigenic SpecificityEF-Hand Calcium Binding Domain 4B (EFCAB4B) (Middle Region)
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman
Isotypen/a
Formataffinity purified
Size50 µg
Concentrationn/a
ApplicationsWestern Blotting (WB)
Reviews / RatingsIf you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
DescriptionEFCAB4B is a Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. It acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.
ImmunogenEFCAB4 B antibody was raised using the middle region of EFCAB4 corresponding to a region with amino acids KNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQ
Other NamesCRACR2A|Gm1073|Gm462
Gene, Accession #Gene ID: 84766
Catalog #ABIN631725
Price
Order / More InfoEF-Hand Calcium Binding Domain 4B (EFCAB4B) (Middle Region) Antibody from ANTIBODIES-ONLINE GmbH
Product Specific Referencesn/a
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