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| Product Name | HUS1, aa1-280, Recombinant, Human (Checkpoint Protein HUS1, hHUS1, HUS1) |
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| Description | Purity ~95% (SDS-PAGE). HUS1 is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex. This protein associates with Rad9 and Rad1 to form the 9-1-1 (RAD9-RAD1-HUS1) complex, which localizes to DNA lesions and promotes DNA damage signaling and repair or apoptosis, cell cycle arrest. The trimeric complex is structurally similar to the proliferating cell nuclear antigen (PCNA) sliding clamp and interacts with Rad17 as a clamp-clamp loader pair during the DNA damage response. Source: Recombinant corresponding to human HUS1, fused to His-tag at N-terminus, expressed in E. coli. Molecular Weight: ~33.8kD Sequences of Amino Acids: MGSSHHHHHH SSGLVPRGSH MKFRAKIVDG ACLNHFTRIS NMIAKLAKTC TLRISPDKLN FILCDKLANG GVSMWCELEQ ENFFNEFQME GVSAENNEIY LELTSENLSR ALKTAQNARA LKIKLTNKHF PCLTVSVELL SMSSSSRIVT HDIPIKVIPR KLWKDLQEPV VPDPDVSIYL PVLKTMKSVV EKMKNISNHL VIEANLDGEL NLKIETELVC VTTHFKDLGN PPLASESTHE DRNVEHMAEV HIDIRKLLQF LAGQQVNPTK ALCNIVNNKM VHFDLLHEDV SLQYFIPALS |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | HUS1 Checkpoint Homolog (S. pombe) |
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| Gene, Accession, CAS # | Accession: NP_004498 |
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| Catalog # | H7967-97A |
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| Order / More Info | HUS1, aa1-280, Recombinant, Human (Checkpoint Protein HUS1, hHUS1, HUS1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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