| 产品详情 |
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| Product Name | Recombinant Human DNA (cytosine-5)-methyltransferase 3A (DNMT3A), partial |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 29.9kDa. Partial: 680-902aa. N-terminal 6xHis-tagged. Homo sapiens (Human). Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | DNA methyltransferase HsaIIIA; DNA MTase HsaIIIA; M.HsaIIIA |
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| Gene, Accession, CAS # | DNMT3A, UniProt: Q9Y6K1 |
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| Catalog # | RPC23795 |
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| Price | |
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| Order / More Info | Recombinant Human DNA (cytosine-5)-methyltransferase 3A (DNMT3A), partial from BIOMATIK |
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| Product Specific References | n/a |
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