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| Product Name | Recombinant Human DNA (cytosine-5)-methyltransferase 3A |
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| Description | 680-902aa; Partial. MW: 29.9kD. Purity >90% as determined by SDS-PAGE. Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required |
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| Size | 0.01 mg (E-Coli), 0.05 mg (E-Coli), 0.1 mg (E-Coli), 0.2 mg (E-Coli), 0.5 mg (E-Coli) |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [DNA methyltransferase HsaIIIA; DNA MTase HsaIIIA; M.HsaIIIA ] |
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| Gene, Accession, CAS # | DNMT3A, Gene ID: 1788, Accession: NP_072046.2 |
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| Catalog # | MBS1265409 |
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| Order / More Info | Recombinant Human DNA (cytosine-5)-methyltransferase 3A from MYBIOSOURCE INC. |
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| Product Specific References | Cloning, expression and chromosome locations of the human DNMT3 gene family.Xie S., Wang Z., Okano M., Nogami M., Li Y., He W.-W., Okumura K., Li E.Gene 236:87-95(1999) A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation.Chen T., Ueda Y., Xie S., Li E.J. Biol. Chem. 277:38746-38754(2002) Co-operation and communication between the human maintenance and de novo DNA (cytosine-5) methyltransferases.Kim G. |
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