| 产品详情 |
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| Product Name | Recombinant Human DNA-binding protein Ikaros (IKZF1) |
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| Description | Purity > 85% as determined by SDS-PAGE. MW: 56.8kDa. Full Length: 1-477aa. N-terminal 6xHis-Avi-tagged. Homo sapiens (Human). Transcription regulator of hematopoietic cell differentiation. Binds gamma-satellite DNA. Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer of the CD3-delta gene. Repressor of the TDT gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF, in a single complex, to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells. Function is isoform-specific and is modulated by dominant-negative inactive isoforms. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Ikaros family zinc finger protein 1 (Lymphoid transcription factor LyF-1) (IK1) (IKAROS) (LYF1) (ZNFN1A1) |
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| Gene, Accession, CAS # | IKZF1, UniProt: Q13422 |
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| Catalog # | RPC25804 |
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| Order / More Info | Recombinant Human DNA-binding protein Ikaros (IKZF1) from BIOMATIK |
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| Product Specific References | n/a |
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