产品名称 Choline O-Acetyltransferase (CHAT) (aa 70-120) Antibody from ANTIBODIES-ONLINE GmbH
产品货号 ABIN349981
产品价格 现货询价,电话:010-67529703
产品规格 100 µL
产品品牌 ANTIBODIES-ONLINE GmbH
产品概述
产品详情
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Antigenic SpecificityCholine O-Acetyltransferase (CHAT) (aa 70-120)
Clonepolyclonal
Host SpeciesRabbit
Reactive Speciesmouse, rat, human
Isotypen/a
Formatserum
Size100 µL
Concentrationn/a
ApplicationsImmunohistochemistry (IHC)
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DescriptionCholinergic systems are implicated in numerous neurologic functions. Alteration in some cholinergic neurons may account for the disturbances of Alzheimer disease. The protein encoded by this gene synthesizes the neurotransmitter acetylcholine. Alternative splice variants have been found that contain alternative 5' untranslated exons. Three of the four described splice variants encode identical 69 kDa proteins while one variant encodes both the 69 kDa and a larger 82 kDa protein. Choline acetylase catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.Catalytic activity: Acetyl-CoA + choline = CoA + O-acetylcholine. Defects in CHAT are the cause of familial infantile myasthenia gravis 2 (FIMG2), also known as CMS-EA. FIMG2 patients have myasthenic symptoms since birth or early infancy, negative tests for anti-AChR antibodies, and abrupt episodic crises with increased weakness, bulbar paralysis, and apnea precipitated by undue exertion, fever, or excitement. Inheritance is autosomal recessive. Also known as: CHOACTase, choline acetylase, choline O-acetyltransferase, CMS1A, CMS1A2, B230380D24Rik.
ImmunogenA synthetic peptide from aa region 70-120 of mouse ChAT conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and human.
Other NamesB230380D24Rik|CHOACTASE|CMS1A|CMS1A2|ChoAcTase
Gene, Accession #Gene ID: 1103,12647,290567
Catalog #ABIN349981
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Order / More InfoCholine O-Acetyltransferase (CHAT) (aa 70-120) Antibody from ANTIBODIES-ONLINE GmbH
Product Specific ReferencesPubMed: 1784419, 3183663, 1388731, 1337937
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