| 产品详情 |
| Edit |   |
|---|
| Product Name | Thymic Stromal Lymphopoietin (TSLP) protein |
|---|
| Description | Thymic Stromal Lymphopoietin TSLP is a hemopoietic protein that is expressed in the heart, liver and prostate. TSLP overlaps biological activities with IL-7 and binds with the heterodimeric receptor complex consisting of the IL-7R alpha chain (IL-7Ralpha) and the TSLP-specific chain (TSLPR). Like IL-7, TSLP induces phosphorylation of STAT3 and STAT5, but uses kinases other than the JAKs for activation. TSLP prohibited apoptosis and stimulated growth of the human acute myeloid leukemia (AML)-derived cell line MUTZ3. It induces the release of T cell-attracting chemokines TARC and MDC from monocytes and activates CD11c(+) dendritic cells (DCs). TSLP activated DCs primed naive T cells to produce the proallergic cytokines (IL-4, IL-5, IL-13, TNFalpha) while down-regulating IL-10 and IFN-gamma suggesting a role in initiating allergic inflammation. |
|---|
| Size | 10 µg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | TSLP |
|---|
| Gene, Accession, CAS # | Gene ID: 85480 |
|---|
| Catalog # | ABIN1540555 |
|---|
| Price | |
|---|
| Order / More Info | Thymic Stromal Lymphopoietin (TSLP) protein from ANTIBODIES-ONLINE GmbH |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|