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| Product Name | Insulin-Like Growth Factor 2 (IGF2) (AA 25-91), (Isoform 1) (Active) protein |
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| Description | Insulin-like Growth Factor II (IGF-II) is a single chain 7 kDa polypeptide, and shares a high degree of homology with insulin. During circulation in vivo, IGF-II is complexed to high affinity binding proteins, IGF Binding Proteins (IGFBP), which act as circulating reservoirs, transport IGF-II, and prolong the half life of IGF-II. The receptors of IGF-II (IGFRs) are transmembrane tyrosine receptors, and are heterotetrameric consisting of two alpha-subunits and two beta-subunits. IGFRs execute their role via intracellullar signaling molecules, such as IRS, shc, and PI3K. The functions of IGF-II include promoting cell survival, growth, proliferation, differentiation and motility. In particular, IGF-II promotes proliferation, inhibits death, and stimulates transformation in breast cancer cells.Recombinant human Insulin-like Growth Factor II (rhIGF-II) produced in E. coli is a single non-glycosylated polypeptide chain containing 68 amino acids. A fully biologically active molecule, rhIGF-II has a molecular mass of 7.6 kDa analyzed by reducing SDS-PAGE. Synonyms: Insulin-like Growth Factor-II, Somatamedin A |
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| Size | 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | LOC100136550|IGF-II|igf2|igf2b|wu:fc26e03|zgc:91781|igf-2|insigf|pp9974|AL033362|Igf-2|Igf-II|M6pr|Mpr|Peg2|IGFII|RNIGF2 |
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| Gene, Accession, CAS # | Gene ID: 3481 |
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| Catalog # | ABIN2017988 |
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| Order / More Info | Insulin-Like Growth Factor 2 (IGF2) (AA 25-91), (Isoform 1) (Active) protein from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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