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| Product Name | Recombinant Mouse Beclin-1 (Becn1) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 67.6kDa. Full Length: 1-448aa. N-terminal 6xHis-SUMO-tagged. Mus musculus (Mouse). Plays a central role in autophagy (PubMed:10604474, PubMed:12372286, PubMed:19270693). Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (PubMed:19270693, PubMed:25275521). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms (PubMed:25275521). Involved in endocytosis including endosome formation in neuronal cells (PubMed:25275521). May play a role in antiviral host defense (By similarity). |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Coiled-coil myosin-like BCL2-interacting protein |
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| Gene, Accession, CAS # | Becn1, UniProt: O88597 |
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| Catalog # | RPC20976 |
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| Order / More Info | Recombinant Mouse Beclin-1 (Becn1) from BIOMATIK |
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| Product Specific References | n/a |
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