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| Antigenic Specificity | Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7) (N-Term), (Extracellular Domain) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | immunogen affinity purified |
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| Size | 40 µg |
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| Concentration | n/a |
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| Applications | Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CHRNA7 (Also known as Nicotinic Acetylcholine Receptor alpha 7) is a major component of brain nicotinic receptors that are blocked by alpha-bungarotoxin. The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. CHRNA7 has a signal peptide, followed by an N-terminal extracellular domain, 3 membrane-spanning regions, an intracellular domain, a fourth transmembrane region, and an extracellular C-terminal tail. The nicotinic acetylcholine receptor alpha-7 subunit is required for acetylcholine inhibition of macrophage TNF release. The nicotinic acetylcholine receptor alpha-7 subunit is essential for inhibiting cytokine synthesis by the cholinergic antiinflammatory pathway. Upregulation of CHRNA7 receptors may be a compensatory response to maintain basocortical cholinergic activity during disease progression or may act with beta-amyloid in disease pathogenesis |
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| Immunogen | KLH-coupled synthetic peptide from N-terminal extracellular domain of human CHRNA7 P36544 |
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| Other Names | CHRNA7-2|NACHRA7|BTX|NARAD|nAChRa7|Acra7|alpha7 |
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| Gene, Accession # | Gene ID: 1139,11441,25302 |
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| Catalog # | ABIN1842566 |
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| Order / More Info | Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7) (N-Term), (Extracellular Domain) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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