产品名称 Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7) (N-Term), (Extracellular Domain) Antibody from ANTIBODIES-ONLINE GmbH
产品货号 ABIN2017586
产品价格 现货询价,电话:010-67529703
产品规格 100 µg
产品品牌 ANTIBODIES-ONLINE GmbH
产品概述
产品详情
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Antigenic SpecificityCholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7) (N-Term), (Extracellular Domain)
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman
Isotypen/a
Formatimmunogen affinity purified
Size100 µg
Concentrationn/a
Applicationsn/a
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DescriptionCHRNA7 (Also known as Nicotinic Acetylcholine Receptor alpha 7) is a major component of brain nicotinic receptors that are blocked by alpha-bungarotoxin. The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. CHRNA7 has a signal peptide, followed by an N-terminal extracellular domain, 3 membrane-spanning regions, an intracellular domain, a fourth transmembrane region, and an extracellular C-terminal tail. The nicotinic acetylcholine receptor alpha-7 subunit is required for acetylcholine inhibition of macrophage TNF release. The nicotinic acetylcholine receptor alpha-7 subunit is essential for inhibiting cytokine synthesis by the cholinergic antiinflammatory pathway. Upregulation of CHRNA7 receptors may be a compensatory response to maintain basocortical cholinergic activity during disease progression or may act with beta-amyloid in disease pathogenesis.
ImmunogenKLH-coupled synthetic peptide from N-terminal extracellular domain of human CHRNA7.
Other NamesCHRNA7-2|NACHRA7|BTX|NARAD|nAChRa7|Acra7|alpha7
Gene, Accession #Gene ID: 1139
Catalog #ABIN2017586
Price
Order / More InfoCholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7) (N-Term), (Extracellular Domain) Antibody from ANTIBODIES-ONLINE GmbH
Product Specific Referencesn/a
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