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| Product Name | SMT3 Suppressor of Mif Two 3 Homolog 3 (S. Cerevisiae) (SUMO3) protein (FITC) |
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| Description | Small Ubiquitin-like Modifier 3 (SUMO3), also known as SMT3A, is synthesized as a 103 amino acid (aa), propeptide with a predicted 11. 5 kDa. SUMO3 contains a two aa C-terminal prosegment. Human SUMO3 shares 83% sequence identity with mouse SUMO3. SUMO3 also has high aa sequence homology to SUMO2 and SUMO4, 87% and 75%, respectively. SUMO3 shares only 47% sequence identity with SUMO1. SUMOs are a family of small, related proteins that can be enzymatically attached to a target protein by a post-translational modification process termed SUMOylation. All SUMO proteins share a conserved ubiquitin domain and a C-terminal diglycine cleavage/attachment site. Following prosegment cleavage, the C-terminal glycine residue of SUMO3 is enzymatically attached to a lysine residue on a target protein. In humans, SUMO3 is conjugated to a variety of molecules in the presence of the SAE1/UBA2 SUMO-activating (E1) enzyme and the UBE2I/Ubc9 SUMO-conjugating (E2) enzyme. In yeast, the SUMO-activating (E1) enzyme is Aos1/Uba2p. Because of the high level of sequence homology most studies report effects of SUMO2/3. For example, addition of SUMO2/3 was shown to modulate the function of ARHGAP21, a RhoGAP protein known to be involved in cell migration. Other reports indicate that the conjugation by SUMO2/3, but not SUMO1, may represent an important mechanism to protect neurons during episodes of cerebral ischemia. However, studies suggest that SUMO2/3 expression is regulated in an isoform-specific manner since oxidative stress downregulated the transcription of SUMO3, but not SUMO2. SUMOylation can occur without the requirement of a specific E3 ligase activity, where SUMO is transferred directly from UbcH9 to specific substrates. SUMOylated substrates are primarily localized to the nucleus (RanGAP-1,RANBP2, PML, p53, Sp100, HIPK2) but there are also cytosolic substrates (IkappaBalpha, GLUT1,GLUT4). SUMO modification has been implicated in functions such as nuclear transport, chromosome segregation, transcriptional regulation, cancer and protein stability. |
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| Size | 50 µg |
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| Concentration | n/a |
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| Applications | SDS-PAGE (SDS) |
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| Other Names | smt3a|smt3h1|fa94a11|im:7141764|sumo2|sumo3|sumo3l|wu:fa94a11|wu:fb55d09|zgc:65847|zgc:85643|fc66f10|fl11h12|wu:fc66f10|wu:fl11h12|zgc:86902|SUMO3|HSMT3|SMT3B|SMT3H2|Smt3A|SMT3A|SMT3H1|SUMO-3|Smt3B|ATSUMO3|MCO15.12|MCO15_12|SMALL UBIQUITIN-LIKE MODIFIER 3|SUM3|SUMO 3|small ubiquitin-like modifier 3|2810014B19Rik|AA409334|AW121497|AW536077|D10Ertd345e|Smt3h1 |
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| Gene, Accession, CAS # | Gene ID: 6612 |
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| Catalog # | ABIN2745855 |
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| Order / More Info | SMT3 Suppressor of Mif Two 3 Homolog 3 (S. Cerevisiae) (SUMO3) protein (FITC) from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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