| 产品详情 |
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| Product Name | LAQ824 |
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| Description | Purity >95%. LAQ824 is a hydroxamate-based inhibitor of histone deacetylases (HDACs) with an IC50 value of 30 nM. It inhibits the growth of colon, breast, prostate, and non-small cell lung cancer cell lines at concentrations of less than 1 µM. LAQ824 augments the actions of fludarabine and imatinib mesylate in human leukemia cells. Through its effects on HDACs, LAQ824 induces acetylation of histones, Alpha-tubulin, and heat shock protein 90 (Hsp90). Acetylation of Hsp90 blocks its chaperone function, resulting in changes in levels of several client proteins, including estrogen receptor-Alpha, Hsp72, and Raf-1. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (2E)-N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide, Dacinostat, NVP-LAQ824 |
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| Gene, Accession, CAS # | CAS: 404951-53-7 |
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| Catalog # | LS-H8412 |
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| Price | |
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| Order / More Info | LAQ824 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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