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Antigenic Specificity | Neural Cell Adhesion Molecule 1 (NCAM1) |
Clone | 123C3 |
Host Species | Mouse |
Reactive Species | human, zebrafish |
Isotype | IgG1 |
Format | purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Flow Cytometry (FACS),Immunocytochemistry (ICC),Immunohistochemistry (IHC),Immunohistochemistry (Frozen Sections) (IHC (fro)),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)),Western Blotting (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | NCAM, as a member of the immunoglobulin superfamily of adhesion molecules is characterized by several immunoglobulin (Ig)-like domains. The extracellular part of NCAM consists of five of these Ig domains and two fibronectin type III homology regions. NCAM is encoded by a single copy gene composed of 26 exons. However, at least 20-30 distinct isoforms can be generated by alternative splicing and by posttranslational modifications, such as sialylation. During sialylation, polysialic acid (PSA) carbohydrates are attached to the extracellular part of NCAM. Through its extracellular region, NCAM mediates homophilic interactions. In addition, NCAM can also undergo heterophilic interactions by binding extracellular matrix components, such as laminin, or other cell adhesion molecules, such as integrins. |
Immunogen | 123C3 is a mouse monoclonal IgG1 antibody derived by fusion of mouse myeloma cells with spleen cells from a mouse immunized with the a membrane preparation of a small cell lung carcinoma specimen. |
Other Names | NCAM1|ncam|n-cam|CD56|MSK39|NCAM|E-NCAM|NCAM-1|Ncam|Cd56|N-CAM|N-CAM-1|NCAM-C|NCAMC|fj56g09|ncam1|wu:fj56g09 |
Gene, Accession # | Gene ID: 4684 |
Catalog # | ABIN335374 |
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Order / More Info | Neural Cell Adhesion Molecule 1 (NCAM1) Antibody from ANTIBODIES-ONLINE GmbH |
Product Specific References | PubMed: 7515028, 1851619, 2837665, 2153450, 2832332 |
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