| 产品详情 |
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| Product Name | VU0467154 |
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| Description | A positive allosteric modulator of the M4 muscarinic acetylcholine receptor; potentiates acetylcholine responses in CHO cells expressing M4 receptors (EC50s = 17.7, 630, and 1,000 nM for rat, human, and cynomolgus monkey receptors, respectively); selective for M4 over M1-3 and M5 receptors and a panel of receptors, transporters, and cation channels at 10 µM; reverses amphetamine-induced hyperlocomotion in rats from 3-56.6 mg/kg; reverses MK-801-induced hyperlocomotion, deficits in a pairwise visual discrimination task, and impairments in the acquisition of contextual fear conditioning in wild-type mice; increases freezing behavior in contextual and tone fear conditioning tests in wild-type mice when administered prior to the conditioning session from 3-30 mg/kg; reduces motor incoordination and prevents decreases in locomotion in the YAC128 transgenic mouse model of Huntington's disease at 10 mg/kg |
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| Size | 5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | VU-0467154 M2 M3 MK801 YAC-128 |
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| Gene, Accession, CAS # | CAS: 1451993-15-9 |
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| Catalog # | 25555-5 |
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| Price | |
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| Order / More Info | VU0467154 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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