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| Product Name | BH3 Interacting Domain Death Agonist (BID) (truncated) protein |
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| Description | Truncated BH3 interacting domain death agonist is a truncated form of the pro-apoptotic full-length BID. Truncated BH3 interacting domain death agonist is generated by Caspase-8 cleavage of BID. The truncated form of the protein translocates from the cytosol to mitochondria and transduces apoptotic signals. BID is a pro-apoptotic Bcl-2 protein having only the BH3 domain. In reaction to apoptotic signaling, BID interacts with another Bcl-2 family of cell death regulators, called Bax, they form a heterodimer resulting to the insertion of Bax into the outer mitochondrial membrane. Bax induces the opening of the mitochondrial voltage-dependent anion channel which lead to the release of cytochrome c and other pro-apoptotic factors from the mitochondria resulting in activation of caspases. BID is a mediator of mitochondrial damage induced by caspase-8 (CASP8). CASP8 cleaves BID, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. The major proteolytic product p15 BID releasea cytochrome c. Isoform 1, Isoform 2 and Isoform 4 induce ice-like proteases and apoptosis while Isoform 3 does not induce apoptosis Synonyms: Truncated BH3-interacting domain death agonist, p22 BID, BID, FP497, MGC15319, MGC42355, tBID |
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| Size | 2 µg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | BID|bid|si:ch211-238n5.6|fp497|xbid|DKFZp469E066|FP497|2700049M22Rik|AI875481|AU022477 |
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| Gene, Accession, CAS # | Gene ID: 12122 |
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| Catalog # | ABIN807392 |
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| Order / More Info | BH3 Interacting Domain Death Agonist (BID) (truncated) protein from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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