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| Product Name | Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) protein |
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| Description | PDCD4 is restricted to the nucleus in proliferating cells. Expression of PDCD4 is modulated by cytokines in natural killer and T cells. PDCD4 takes part in apoptosis. PDCD4 is a translation inhibitor targeted for degradation during tumor promotion. PDCD4 promotes colonic neoplastic transformation and tumor invasion. PDCD4 is an important target for microrna R-21 in breast cancer cells. Shortage of PDCD4 expression is associated with colorectal cancer. PDCD4 is swiftly phosphorylated by S6K1 kinase protein and afterwords degraded by ubiquitin ligase SCF in response to mitogens. PDCD4 in response to mitogens allows competent protein synthesis and cell growth. PDCD4 is a proapoptotic protein involved in TGF-beta1-induced apoptosis in human HCC cells, and a tumor suppressor in hepatocarcinogenesis. PDCD4 restraines tumor progression in colon carcinoma cells by the novel mechanism of down-regulating MAP4K1 transcription, with consequent inhibition of c-Jun activation and AP-1-dependent transcription. Overexpression of PDCD4 in carcinoid cells results in inhibition of cell proliferation Synonyms: Programmed cell death protein 4, Nuclear antigen H731-like, Neoplastic transformation inhibitor protein, Protein 197/15a, PDCD4, H731, MGC33046, MGC33047 |
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| Size | 2 µg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | h731|MGC69337|PDCD4|D19Ucla1|Ma3|Tis|Dug|H731 |
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| Gene, Accession, CAS # | Gene ID: 27250 |
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| Catalog # | ABIN807335 |
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| Order / More Info | Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) protein from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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