| 产品详情 |
| Edit |   |
|---|
| Product Name | SCH 529074 |
|---|
| Description | An activator of p53; restores DNA binding activity and increases DNA binding affinity of two recombinant GST fusion mutant p53 DNA binding domains (R273H and R249S) in an electrophoretic mobility shift assay (Kds = 0.6740 and 0.4313, respectively); stimulates DNA binding activity and prevents Hdm-2 ubiquitination of wild-type p53 in vitro; reduces proliferation of tumor cell lines with mutant and wild-type p53 (EC50s = 400-3,700 nM); reduces tumor growth in a DLD-1 human colorectal cancer xenograft model in mice in a dose-dependent manner |
|---|
| Size | 5 mg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | p-53 oncogenic HDM2 anti-tumor antitumor SCH529074 DLD1 |
|---|
| Gene, Accession, CAS # | CAS: 922150-11-6 |
|---|
| Catalog # | 21552-5 |
|---|
| Price | |
|---|
| Order / More Info | SCH 529074 from CAYMAN CHEMICAL COMPANY |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|