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| Product Name | Recombinant Human Cartilage intermediate layer protein 1 (CILP), partial |
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| Description | Purity > 85% as determined by SDS-PAGE. MW: 95.7kDa. Partial: 725-1184aa. N-terminal MBP-tagged and C-terminal 6xHis-tagged. Homo sapiens (Human). Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Cartilage intermediate-layer protein |
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| Gene, Accession, CAS # | CILP, UniProt: O75339 |
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| Catalog # | RPC26358 |
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| Order / More Info | Recombinant Human Cartilage intermediate layer protein 1 (CILP), partial from BIOMATIK |
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| Product Specific References | n/a |
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