| 产品详情 |
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| Antigenic Specificity | Antithrombin III |
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| Clone | polyclonal |
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| Host Species | Sheep |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | ion exchange purified |
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| Size | 1 mL |
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| Concentration | n/a |
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| Applications | Anti-Human antithrombin III was tested by IEP, radial immunodiffusion (RID), and double diffusion. May be useful in additional assays. Specific conditions for reactivity should be optimized by the end user. |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | This polyclonal antibody is directed against human antithrombin III and is an IgG fraction purification by precipitation and anion exchange chromatography. Cross reactivity to other species has not been tested. Lot variation tested and limited to ±20% by radial Immunodiffusion (RID). Antithrombin, termed Antithrombin III (AT III), is the most important inhibitor of thrombin and other coagulation proteinases. It belongs to the serine proteinase inhibitor (serpin) superfamily of inhibitors and structurally related proteins, which contain reactive centers that have evolved to attract and entrap certain proteinases. Inherited antithrombin III deficiency (AT3D) is a risk factor for the early development of venous thromboembolism (THPH7). Antithrombin III regulates clot formation both by inhibiting thrombin activity directly and by interfering with earlier stages of the clotting cascade. By in situ hybridization and quantitative analysis of DNA dosage in carriers of chromosome 1 deletions, AT3 is mapped to 1q23-q25. The AT3 gene has 7 exons. It contains 9 complete and 1 partial repetitive ALU sequence elements, which occur in the introns of the gene at a higher frequency (about 22% of the intron sequence) than in the genome as a whole (about 5%). Anti-Human Antithrombin III (ATIII) Antibody is useful for researchers interested in cardiovascular research. |
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| Immunogen | Anti-Human antithrombin III was produced in sheep by repeated immunizations with human antithrombin III, purified from plasma, shown to be homogeneous by SDS-PAGE. |
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| Other Names | Sheep Anti-Human Antithrombin III Antibody, Anti-ATIII, Sheep Anti-Antithrombin III Antibody, AT III |
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| Gene, Accession # | SERPINC1, Gene ID: 462, UniProt: P01008, NCBI: NP 000479.1 |
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| Catalog # | 200-601-MC3 |
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| Price | |
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| Order / More Info | Antithrombin III Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
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| Product Specific References | n/a |
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