产品名称 Baculoviral IAP Repeat-Containing 5 (BIRC5) (C-Term) Antibody from ANTIBODIES-ONLINE GmbH
产品货号 ABIN181412
产品价格 现货询价,电话:010-67529703
产品规格 0.5 mg
产品品牌 ANTIBODIES-ONLINE GmbH
产品概述
产品详情
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Antigenic SpecificityBaculoviral IAP Repeat-Containing 5 (BIRC5) (C-Term)
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman, mouse
Isotypen/a
FormatProtein A purified
Size0.5 mg
Concentrationn/a
ApplicationsImmunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Reviews / RatingsIf you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
DescriptionSurvivin, a new inhibitor of apoptosis (IAP) protein, is expressed in the G2/M phase of the cell cycle in a cycle-regulated manner. At the beginning of mitosis, survivin associates with microtubules of the mitotic spindle in a specific and saturable reaction that is regulated by microtubule dynamics. Disruption of survivin-microtubule interactions results in loss of survivin's antiapoptosis function and increased caspase-3 activity, a mechanism involved in cell death, during mitosis. It indicates that survivin may counteract a default induction of apoptosis in G2/M phase. The overexpression of survivin in cancer may overcome this apoptotic checkpoint and favour aberrant progression of transformed cells through mitosis.Synonyms: API4, Apoptosis inhibitor 4, Apoptosis inhibitor survivin, Baculoviral IAP repeat-containing protein 5, Survivin
ImmunogenA synthetic peptide derived from the C-terminus of survivin
Other NamesAPI4|EPR-1|AAC-11|Api4|TIAP|survivin40|AP14
Gene, Accession #n/a
Catalog #ABIN181412
Price
Order / More InfoBaculoviral IAP Repeat-Containing 5 (BIRC5) (C-Term) Antibody from ANTIBODIES-ONLINE GmbH
Product Specific ReferencesPubMed: 9581817, 9859993, 9256286
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