| 产品详情 |
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| Antigenic Specificity | Baculoviral IAP Repeat Containing 2 (BIRC2) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | mouse, rat, human |
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| Isotype | n/a |
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| Format | affinity purified |
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| Size | 50 µg |
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| Concentration | n/a |
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| Applications | Western Blotting (WB),Immunohistochemistry (IHC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | The inhibitor of apoptosis protein (IAP) family consists of an evolutionarily conserved group of apoptosis inhibitors containing a conserved 70 amino acid BIR (baculovirus inhibitor repeat) domain . Human members of this family include c-IAP1, c-IAP2, XIAP, survivin, livin, and NAIP. Overexpression of IAP family members, particularly survivin and livin, in cancer cell lines and primary tumors suggests an important role for these proteins in cancer progression . In general, the IAP proteins function through direct interactions to inhibit the activity of several caspases, including caspase-3, caspase-7, and caspase-9 . In addition, binding of IAP family members to the mitochondrial protein Smac blocks their interaction with caspase-9, thereby allowing the processing and activation of the caspase . Synonyms: BIRC2,API1,HIAP2,Hiap-2,MIHB,RNF48,cIAP1 , |
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| Immunogen | Recombinant protein of human BIRC2 |
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| Other Names | Api1|Api2|IAP1|IAP2|MIHB|MIHC|Birc2|HIAP2|MIAP1|MIAP2|RNF49|cIAP1|cIAP2|cIAP-1|cIAP-2|AW107670|ciap-1|API1|Hiap-2|RNF48|c-IAP1|ITA|AW146227|Birc3|HIAP1|mcIAP1|rIAP1|RGD1559914 |
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| Gene, Accession # | Gene ID: 329,11797,60371 |
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| Catalog # | ABIN1683408 |
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| Price | |
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| Order / More Info | Baculoviral IAP Repeat Containing 2 (BIRC2) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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