| 产品详情 |
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| Antigenic Specificity | RB1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | affinity purified |
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| Size | 100 ul |
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| Concentration | n/a |
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| Applications | WB |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Rabbit polyclonal to RB1.Retinoblastoma-associated protein b) is a tumor suppressor and a key regulator of entry into celldivision. RB1 acts as a transcription repressor of E2F1 target genes. The hypophosphorylated, activeform of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest.RB1 is directly involved in heterochromatin formation by maintaining overall chromatin structure and,in particular, that of constitutive heterochromatin by stabilizing histone methylation. When it is time fora cell to enter S phase, complexes of cyclin-dependent kinases (CDK) and cyclins phosphorylate RB1and inhibit its activity. |
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| Immunogen | middle region of human RB1 |
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| Other Names | RB1,Retinoblastomaassociated protein,p105Rb,pRb,pp110,Rb |
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| Gene, Accession # | UniProt: P06400 |
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| Catalog # | orb66933 |
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| Price | |
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| Order / More Info | RB1 Antibody from BIORBYT LTD. |
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| Product Specific References | n/a |
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| 产品资料 |
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