产品名称 Suppressor of Cytokine Signaling 3 (SOCS3) (N-Term) Antibody from ANTIBODIES-ONLINE GmbH
产品货号 ABIN927112
产品价格 现货询价,电话:010-67529703
产品规格 100 µg
产品品牌 ANTIBODIES-ONLINE GmbH
产品概述
产品详情
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Antigenic SpecificitySuppressor of Cytokine Signaling 3 (SOCS3) (N-Term)
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman
Isotypen/a
Formataffinity purified
Size100 µg
Concentrationn/a
ApplicationsWestern Blotting (WB)
Reviews / RatingsIf you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
DescriptionThe Janus family of protein tyrosine kinases (JAKs) and STAT transcription factors regulate cellular processes involved in cell growth, differentiation, and transformation through their association with cytokine receptors. The CIS family of proteins (also referred as the SOCS or SSI family) has been implicated in the regulation of signal transduction by a variety of cytokines. The cytokine-inducible SH2 protein 3 (CIS3/SOCS3/SSI3) has been shown to inhibit the JAK/STAT pathway and act as a negative regulator of fetal liver erythropoiesis. Recently, it is reported that CIS3 regulates the erythropoietin (EPO) receptor (EPOR) signaling in erythroid progenitors and Ba/F3 cells expressing the EPOR (BFER). CIS3 binds directly to the EPOR as well as JAK2 and inhibits EPOdependent proliferation and STAT5 activation. It is reported that JAB/SOCS1 is strongly induced by interferongamma and forced expression of JAB/SOCS1 conferred cells interferon resistance. This resistance was caused by inhibition of JAK1 and JAK2 activation in response to IFN gamma. Moreover, recent detailed analysis of JAB/SOCS1 knockout mice revealed that JAB/SOCS1 is indeed a negative feedback regulator that determines the sensitivity of cells to IFN gamma. Description: Serum. Synonyms: Polyclonal SOCS antibody, Anti-SOCS3 antibody, CIS3 antibody, STAT-induced STAT inhibitor 3 antibody, Cytokine-inducible SH2 protein 3 antibody, ATOD4 antibody.
ImmunogenCIS3 antibody was raised in rabbit using a synthetic peptide corresponding to the Nterminal part of Human CIS3/SOCS3 as the immunogenSerum
Other Namessocs3|fj09e12|zgc:56537|wu:fj09e12|MGC64393|MGC75749|xsocs3|MGC81248|atod4|cis3|cish3|socs-3|ssi-3|ssi3|SOCS3|ATOD4|CIS3|Cish3|SOCS-3|SSI-3|SSI3|Cis3|EF-10|Ef10|Ssi3|Socs-3|Ssi-3
Gene, Accession #Gene ID: 9021
Catalog #ABIN927112
Price
Order / More InfoSuppressor of Cytokine Signaling 3 (SOCS3) (N-Term) Antibody from ANTIBODIES-ONLINE GmbH
Product Specific Referencesn/a
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