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| Antigenic Specificity | Calcium/calmodulin-Dependent Protein Kinase IV (CAMK4) |
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| Clone | 3C10-D5-G7 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG2a |
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| Format | affinity purified |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consodilation. In the thymus, regulates the CD4+/CD8+ double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteolclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphrylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18. Subunit structure: Monomer By similarity. Interacts with protein phosphatase 2A (PPP2CA/PPP2CB), the interaction is mutually exclusive with binding to Ca2+/calmodulin. Subcellular location: Cytoplasm. NucleusSequence similarities: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. Contains 1 protein kinase domain. |
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| Immunogen | Purified recombinant human CaMKIV protein fragments expressed in E.coli. |
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| Other Names | CAMK4|camk4-A|CaMK IV|CaMK-GR|IV|caMK|A430110E23Rik|AI666733|CaMKIV|CaMKIV/Gr|D18Bwg0362e|Ccdpk|RATCCDPK|wu:fj42a03|zgc:110275 |
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| Gene, Accession # | Gene ID: 814 |
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| Catalog # | ABIN1558183 |
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| Order / More Info | Calcium/calmodulin-Dependent Protein Kinase IV (CAMK4) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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