| Edit |   |
|---|
| Antigenic Specificity | SET and MYND Domain Containing 2 (SMYD2) |
|---|
| Clone | 1G10-E11-H9 |
|---|
| Host Species | Mouse |
|---|
| Reactive Species | human |
|---|
| Isotype | IgG2b |
|---|
| Format | unconjugated |
|---|
| Size | 100 µL |
|---|
| Concentration | n/a |
|---|
| Applications | Western Blotting (WB) |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | SET domain-containing proteins, such as SMYD2, catalyze lysine methylation (Brown et al. , 2006 [PubMed 16805913]). [supplied by OMIM, Nov 2008]Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Has also methyltransferase activity toward non-histone proteins such as p53/TP53 and RB1. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates 'Lys-860' of RB1/RB. Subunit structure: Interacts with RNA polymerase II and HELZ. Interacts with SIN3A and HDAC1 By similarity. Interacts (via MYND-type zinc finger) with EPB41L3. Interacts (via SET domain) with p53/TP53. Interacts with RB1 and HSP90AA1. Subcellular location: Cytoplasm > cytosol,NucleusSequence similarities: Contains 1 MYND-type zinc finger. Contains 1 SET domain. |
|---|
| Immunogen | Purified recombinant human KMT3C / SMYD2 protein fragments expressed in E.coli. |
|---|
| Other Names | HSKM-B|KMT3C|ZMYND14|1110020E07Rik|4930402C15|Zmynd14|smyd2-a|im:7146196|smyd2|wu:fc02f02|zgc:110553 |
|---|
| Gene, Accession # | Gene ID: 56950 |
|---|
| Catalog # | ABIN1558149 |
|---|
| Price | |
|---|
| Order / More Info | SET and MYND Domain Containing 2 (SMYD2) Antibody from ANTIBODIES-ONLINE GmbH |
|---|
| Product Specific References | n/a |
|---|