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| Product Name | Recombinant Human Histone-lysine N-methyltransferase SETDB1 (SETDB1) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 71.7kDa. Full Length of Isoform 2: 1-397aa. N-terminal GST-tagged. Homo sapiens (Human). Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells. Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing. The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | ERG-associated protein with SET domain |
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| Gene, Accession, CAS # | SETDB1, UniProt: Q15047 |
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| Catalog # | RPC23015 |
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| Order / More Info | Recombinant Human Histone-lysine N-methyltransferase SETDB1 (SETDB1) from BIOMATIK |
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| Product Specific References | n/a |
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