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Antigenic Specificity | ATPase, H+ Transporting, Lysosomal V0 Subunit A4 (ATP6V0A4) (C-Term) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | ATP6V0A4(ATPase, H+ transporting, lysosomal V0 subunit aisoform 4) is a component of vacuolar ATPase(V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. V-ATPase is comprised of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of a hexamer of three A and three B subunits plus the C, D, and E subunits. It contains the ATP catalytic site. The ATP6V0A4 protein is one of three 116 kD subunits family. This family consists of the 116kDa V-type ATPase (vacuolar H+)-ATPases) subunits, as well as V-type ATP synthase subunit i. The V-type ATPases family are proton pumps that acidify intracellular compartments in eukaryotic cells for example yeast central vacuoles, clathrin-coated and synaptic vesicles. They have important roles in membrane trafficking processes. The 116kDa subunit (subunit a) in the V-type ATPase is part of the V0 functional domain responsible for proton transport. The a subunit is a transmembrane glycoprotein with multiple putative transmembrane helices it has a hydrophilic amino terminal and a hydrophobic carboxy terminal. It has roles in proton transport and assembly of the V-type ATPase complex. This subunit is encoded by two homologous gene in yeast VPH1 and STV1 |
Immunogen | Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of Human ATP6V0A4(ATPase, H+ transporting, lysosomal V0 subunit aisoform 4) |
Other Names | A4|ATP6N1B|ATP6N2|RDRTA2|RTA1C|RTADR|STV1|VPH1|VPP2|Atp6n1b|a4 |
Gene, Accession # | Gene ID: 50617 |
Catalog # | ABIN965622 |
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Order / More Info | ATPase, H+ Transporting, Lysosomal V0 Subunit A4 (ATP6V0A4) (C-Term) Antibody from ANTIBODIES-ONLINE GmbH |
Product Specific References | PubMed: 10973252, 10224039, 10577919, 10440860, 10221984 |
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