产品名称 Discs, Large Homolog 1 (Drosophila) (DLG1) (aa 1-104) Antibody from ANTIBODIES-ONLINE GmbH
产品货号 ABIN2482551
产品价格 现货询价,电话:010-67529703
产品规格 100 µg
产品品牌 ANTIBODIES-ONLINE GmbH
产品概述
产品详情
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Antigenic SpecificityDiscs, Large Homolog 1 (Drosophila) (DLG1) (aa 1-104)
CloneS64-15
Host SpeciesMouse
Reactive Specieshuman, mouse, rat
Isotypen/a
Formatalkaline phosphatase (AP) conjugate
Size100 µg
Concentrationn/a
ApplicationsImmunohistochemistry (IHC),Immunoprecipitation (IP),Western Blotting (WB)
Reviews / RatingsIf you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
DescriptionSynapse-Associated Protein 97 (SAP97/human homologue of Drosophila discs-large tumor supressor or HDLG) is one of a family of plasma membrane-associated proteins found in synaptic junctions. This is a novel, presynaptic membrane protein homologous to SAP90 and the Drosophila discs-large tumor supressor protein. SAP97 has three ~90 amino acid repeats called PDZ domains, a single interior SH3 domain, and a carboxyl-terminal guanylate kinase homology (GuK) domain that is enzymatically inactive. It is hypothesized that PDZ-domain interactions play a role in receptor and channel clustering which contributes to neuronal plasticity. SAP97 is believed to participate in the clustering of certain proteins, including N-methyl-D-aspartate (NMDA) receptors and Shaker-type potassium channels at the synaptic membrane. There are two principal modes of interaction between SAP97 and other proteins. NMDA receptors and Shaker-type potassium channels both share C-terminal sequence homology consisting of a threonine/serine-X-valine-COOH (T/SXV) motif. Other neuronal proteins that share this motif (beta 1 adrenergic receptor, some serotonin receptors, some sodium channel subunits, and additional potassium channel subunits) may interact with SAP97 by binding to its PDZ domains. Neuronal nitric oxide synthase (nNOS), which lacks the T/SXV motif but which has its own PDZ domain, has been shown to associate with SAP97 in vitro through a pseudo-homotypic PDZ-PDZ interaction.Cellular Localization: Membrane (Basolateral cell membrane) | Endoplasmic reticulum membrane | Cell Junction | Synapse
ImmunogenFusion protein amino acids 1-104 of rat SAP97
Other NamesDLG1|Dlgh1|SAP97|B130052P05Rik|E-dlg/SAP97|SAP-97|mKIAA4187|DLGH1|dJ1061C18.1.1|hdlg
Gene, Accession #Gene ID: 1739,13383,25252
Catalog #ABIN2482551
Price
Order / More InfoDiscs, Large Homolog 1 (Drosophila) (DLG1) (aa 1-104) Antibody from ANTIBODIES-ONLINE GmbH
Product Specific Referencesn/a
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