| 产品详情 |
| Edit |   |
|---|
| Product Name | Ascomycin |
|---|
| Description | Purity ~95% (HPLC, TLC). Macrolide antibiotic. Ethyl analog of FK506. Strong immunosuppressant. Binds to the FK-506-binding protein FKBP12. This complex inhibits calcineurin (protein phosphatase 2B (PP2B)). Suppresses the production of T helper type 1 (Th1) (interferon and IL-2) and Th2 (IL-4 and IL-10) cytokines in T lymphocytes and preferentially inhibits the activation of mast cells. Anti-inflammatory. Used for topical treatment of inflammatory skin diseases. Potently inhibits anti-IgE-induced histamine and cytokine release and reduces IgE-dependent p38 MAPK activation in human basophils. Inhibits basophil degranulation at the initial phase of allergic skin reactions. Antifungal. Antimalaria compound. Anticonvulsant (antiepileptic). Source: Streptomyces sp. Formula: C43H69NO12 Solubility: DMSO or ethanol Molecular Weight: ~792.0 |
|---|
| Size | 1mg, 5mg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | Ascomycin (High purity) (Immunomycin, FK520, Analog of FK-506, FR-900520, L-683590, NSC 106410, WS 7238A) |
|---|
| Gene, Accession, CAS # | n/a |
|---|
| Catalog # | 207066 |
|---|
| Price | |
|---|
| Order / More Info | Ascomycin from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|