| 产品详情 |
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| Antigenic Specificity | ACO1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | mouse, rat |
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| Isotype | n/a |
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| Format | affinity purified |
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| Size | 50 µl, 100 µl, 200 µl |
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| Concentration | > 1 mg/ml |
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| Applications | WB, IHC. RUO |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | ACO1 Antibody is a Rabbit Polyclonal antibody against ACO1. The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants. |
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| Immunogen | A synthetic peptide of human ACO1. |
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| Other Names | ACO1; Aconitase 1; Iron-Responsive Element-Binding Protein 1; Aconitate Hydratase, Cytoplasmic; Ferritin Repressor Protein; Iron Regulatory Protein 1; Cytosplasmic Aconitase; Aconitase 1, Soluble; Citrate Hydro-Lyase; Soluble Aconitase; IRE-BP 1; IREB1; IRP1; Cytoplasmic Aconitate Hydratase; Epididymis Luminal Protein 60; Aconitase; IREBP1; ACONS; HEL60; IREBP |
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| Gene, Accession # | ACO1, Gene ID: 48, SwissProt: P21399 |
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| Catalog # | abx004618 |
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| Price | |
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| Order / More Info | ACO1 Antibody from ABBEXA |
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| Product Specific References | n/a |
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