产品名称 ACO1 Antibody from ABBEXA
产品货号 abx004618
产品价格 现货询价,电话:010-67529703
产品规格 50 µl, 100 µl, 200 µl
产品品牌 ABBEXA
产品概述
产品详情
Edit&nbsp
Antigenic SpecificityACO1
Clonepolyclonal
Host SpeciesRabbit
Reactive Speciesmouse, rat
Isotypen/a
Formataffinity purified
Size50 µl, 100 µl, 200 µl
Concentration> 1 mg/ml
ApplicationsWB, IHC. RUO
Reviews / RatingsIf you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
DescriptionACO1 Antibody is a Rabbit Polyclonal antibody against ACO1. The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants.
ImmunogenA synthetic peptide of human ACO1.
Other NamesACO1; Aconitase 1; Iron-Responsive Element-Binding Protein 1; Aconitate Hydratase, Cytoplasmic; Ferritin Repressor Protein; Iron Regulatory Protein 1; Cytosplasmic Aconitase; Aconitase 1, Soluble; Citrate Hydro-Lyase; Soluble Aconitase; IRE-BP 1; IREB1; IRP1; Cytoplasmic Aconitate Hydratase; Epididymis Luminal Protein 60; Aconitase; IREBP1; ACONS; HEL60; IREBP
Gene, Accession #ACO1, Gene ID: 48, SwissProt: P21399
Catalog #abx004618
Price
Order / More InfoACO1 Antibody from ABBEXA
Product Specific Referencesn/a
产品资料