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| Product Name | NOX Inhibitor VII, Thr101 |
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| Description | Purity ~98% (HPLC). A cell-permeable, selenium-to-sulfur substituted Ebselen derivative that exhibits similar NOX2 inhibitory activity as Ebselen by blocking p22phox c-terminal PRD (proline-rich domain) and p47phoxbis-SH3 interaction. Although less potent than Ebselen in cell-free p22phox PRD-p47phoxbis-SH3 binding (IC50 = 4 vs. 0.3uM) and NOX2 activity (IC50 = 4 vs. 0.6uM) assays, Thr101 is more potent and NOX2-selective than Ebselen in cell-based assays (Thr101 IC50 /Ebselen IC50 = 0.3/0.5, 3/0.15, 8/no inhibition, 8/0.7uM, respectively, against NOX2, NOX1, NOX4, and NOX5) and exhibits no glutathione peroxidase activity. Primary Target: Blocks p22phox c-terminal PRD (proline-rich domain) and p47phox bis-SH3 interaction Solubility: DMSO (50mg/ml) Atmophere: Inert gas |
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| Size | 25mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | NOX Inhibitor VII, Thr101 (NADPH Oxidase Inhibitor VII, 6-Fluoro-2-o-tolylbenzo[d]isothiazol-3(2H)-one, 6-Fluoro-2-(2-methylphenyl)-1,2-benzothiazol-3(2H)-one) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217599 |
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| Order / More Info | NOX Inhibitor VII, Thr101 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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