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| Product Name | LT175 |
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| Description | Purity >97%. Peroxisome proliferator-activated receptors (PPARs) are activated by fatty acids and eicosanoids as well as antidyslipidemic agents. Among the receptor isotypes, PPAR alpha demonstrates a particular role in fatty acid oxidation whereas PPAR gamma is known to be involved in adipocyte differentiation and lipid storage. LT175 is a dual PPAR alpha / gamma ligand that displays partial agonism toward PPAR gamma (EC50s = 0.22, 0.26, and 0.48 µM for hPPAR alpha, mPPAR alpha, and hPPAR gamma, respectively). It exhibits low adipogenic activity in vitro and improves glucose homeostasis in diet-induced insulin resistant mice. LT175 was shown to disrupt the recruitment of coregulators, cyclic-AMP response element-binding protein-binding protein and nuclear corepressor 1, to PPAR gamma . |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | aS-([1,1'-biphenyl]-4-yloxy)-benzenepropanoic acid |
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| Gene, Accession, CAS # | CAS: 862901-87-9 |
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| Catalog # | LS-H141 |
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| Price | |
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| Order / More Info | LT175 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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