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| Product Name | Recombinant Mouse Thioredoxin-interacting protein (Txnip) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 46.4kDa. Full Length: 1-397aa. N-terminal 6xHis-tagged. Mus musculus (Mouse). May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Vitamin D3 up-regulated protein 1 |
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| Gene, Accession, CAS # | Txnip, UniProt: Q8BG60 |
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| Catalog # | RPC25446 |
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| Order / More Info | Recombinant Mouse Thioredoxin-interacting protein (Txnip) from BIOMATIK |
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| Product Specific References | n/a |
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